Computational design of peptide ligands to target the intermolecular interaction between viral envelope protein and pediatric receptor

@article{Xu2017ComputationalDO,
  title={Computational design of peptide ligands to target the intermolecular interaction between viral envelope protein and pediatric receptor},
  author={Darong Xu and Hongliang Bian and Jinlan Cai and Daocheng Bao and Qing Jin and Min Zhu and Cuifeng Zhang and Tingting Tao},
  journal={Computational biology and chemistry},
  year={2017},
  volume={69},
  pages={120-125}
}
The recognition and binding of viral envelope protein to pediatric receptor subverts the membrane-trafficking apparatus to mediate virion export in young children. Here, we described a successful computational design of peptide ligands to target the intermolecular interaction between the virus large envelope protein (LHB) and adaptin receptor (ADT). Based on the crystal structure of ADT in complex with an oligopeptide segment corresponding to the core binding site of LHB, a sequence-specific… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Self-guided Langevin dynamics simulation method

X. W. Wu, B. R. Brooks
Chem. Phys. Lett • 2003
View 2 Excerpts
Highly Influenced

Rational design of YAP WW1 domain-binding peptides to target TGFβ/BMP/Smad-YAP interaction in heterotopic ossification.

Journal of peptide science : an official publication of the European Peptide Society • 2015
View 2 Excerpts

Self-Binding Peptides: Folding or Binding?

Journal of Chemical Information and Modeling • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…