Computational design of four-helix bundle proteins that bind nonbiological cofactors.

Abstract

Recent work is discussed concerning the computational design of four-helix bundle proteins that form complexes with nonbiological cofactors. Given that often there are no suitable natural proteins to provide starting points in the creation of such nonbiological systems, computational design is well suited for the design and study of new protein-cofactor… (More)
DOI: 10.1021/bp070178q

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