Computational design and selections for an engineered, thermostable terpene synthase.

@article{Diaz2011ComputationalDA,
  title={Computational design and selections for an engineered, thermostable terpene synthase.},
  author={Juan E. Diaz and Chun-Shi Lin and Kazuyoshi Kunishiro and Birte K. Feld and Sara K Avrantinis and Jonathan Bronson and John Greaves and Jeffery G. Saven and Gregory A. Weiss},
  journal={Protein science : a publication of the Protein Society},
  year={2011},
  volume={20 9},
  pages={1597-606}
}
Terpenoids include structurally diverse antibiotics, flavorings, and fragrances. Engineering terpene synthases for control over the synthesis of such compounds represents a long sought goal. We report computational design, selections, and assays of a thermostable mutant of tobacco 5-epi-aristolochene synthase (TEAS) for the catalysis of carbocation… CONTINUE READING