Computational de novo design, and characterization of an A(2)B(2) diiron protein.

@article{Summa2002ComputationalDN,
  title={Computational de novo design, and characterization of an A(2)B(2) diiron protein.},
  author={Christopher M. Summa and Michael M. Rosenblatt and J Hong and James D. Lear and William F. DeGrado},
  journal={Journal of molecular biology},
  year={2002},
  volume={321 5},
  pages={923-38}
}
Diiron proteins are found throughout nature and have a diverse range of functions; proteins in this class include methane monooxygenase, ribonucleotide reductase, Delta(9)-acyl carrier protein desaturase, rubrerythrin, hemerythrin, and the ferritins. Although each of these proteins has a very different overall fold, in every case the diiron active site is situated within a four-helix bundle. Additionally, nearly all of these proteins have a conserved Glu-Xxx-Xxx-His motif on two of the four… CONTINUE READING

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photorealistic molecular graphics

  • E. A. Merrit, Bacon, D. J. . Raster3D
  • Methods Enzymol. 277, 505–524. Edited by P…
  • 2002
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