Computational challenges of structure-based approaches applied to HIV.

@article{Forli2015ComputationalCO,
  title={Computational challenges of structure-based approaches applied to HIV.},
  author={Stefano Forli and Arthur J. Olson},
  journal={Current topics in microbiology and immunology},
  year={2015},
  volume={389},
  pages={
          31-51
        }
}
Here, we review some of the opportunities and challenges that we face in computational modeling of HIV therapeutic targets and structural biology, both in terms of methodology development and structure-based drug design (SBDD). Computational methods have provided fundamental support to HIV research since the initial structural studies, helping to unravel details of HIV biology. Computational models have proved to be a powerful tool to analyze and understand the impact of mutations and to… 
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