Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions.

@article{Kotera2004ComputationalAO,
  title={Computational assignment of the EC numbers for genomic-scale analysis of enzymatic reactions.},
  author={Masaaki Kotera and Yasushi Okuno and Masahiro Hattori and Susumu Goto and Minoru Kanehisa},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 50},
  pages={16487-98}
}
The EC (Enzyme Commission) numbers represent a hierarchical classification of enzymatic reactions, but they are also commonly utilized as identifiers of enzymes or enzyme genes in the analysis of complete genomes. This duality of the EC numbers makes it possible to link the genomic repertoire of enzyme genes to the chemical repertoire of metabolic pathways, the process called metabolic reconstruction. Unfortunately, there are numerous reactions known to be present in various pathways, but they… CONTINUE READING

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