Computational approaches to identify functional genetic variants in cancer genomes

@article{GonzalezPerez2013ComputationalAT,
  title={Computational approaches to identify functional genetic variants in cancer genomes},
  author={Abel Gonzalez-Perez and Ville Mustonen and Boris A. Reva and Graham R. S. Ritchie and Pau Creixell and Rachel Karchin and Miguel Vazquez and J. Lynn Fink and Karin S. Kassahn and John V. Pearson and Gary D. Bader and Paul C. Boutros and Lakshmi B. Muthuswamy and B. F. Francis Ouellette and J{\"u}ri Reimand and Rune Linding and Tatsuhiro Shibata and Alfonso Valencia and Adam Butler and Serge Dronov and Paul Flicek and Nick B Shannon and Hannah Carter and Li Ding and Chris Sander and Josh M. Stuart and Lincoln D. Stein and N{\'u}ria L{\'o}pez-Bigas},
  journal={Nature Methods},
  year={2013},
  volume={10},
  pages={723-729}
}
The International Cancer Genome Consortium (ICGC) aims to catalog genomic abnormalities in tumors from 50 different cancer types. Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only a minority of these drive tumor progression. We present the result of discussions within the ICGC on how to address the challenge of identifying mutations that contribute to oncogenesis, tumor maintenance or response to therapy, and recommend computational techniques to… CONTINUE READING

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The International Cancer Genome Consortium ( ICGC ) aims to catalog genomic abnormalities in tumors from 50 different cancer types .
The International Cancer Genome Consortium ( ICGC ) aims to catalog genomic abnormalities in tumors from 50 different cancer types .
Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only a minority of these drive tumor progression .
Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only a minority of these drive tumor progression .
Genome sequencing reveals hundreds to thousands of somatic mutations in each tumor but only a minority of these drive tumor progression .
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