Computational approaches for the identification of cancer genes and pathways

@inproceedings{Dimitrakopoulos2017ComputationalAF,
  title={Computational approaches for the identification of cancer genes and pathways},
  author={Christos M. Dimitrakopoulos and Niko Beerenwinkel},
  booktitle={Wiley interdisciplinary reviews. Systems biology and medicine},
  year={2017}
}
High-throughput DNA sequencing techniques enable large-scale measurement of somatic mutations in tumors. Cancer genomics research aims at identifying all cancer-related genes and solid interpretation of their contribution to cancer initiation and development. However, this venture is characterized by various challenges, such as the high number of neutral passenger mutations and the complexity of the biological networks affected by driver mutations. Based on biological pathway and network… CONTINUE READING