Computational and experimental identification of C. elegans microRNAs.

  title={Computational and experimental identification of C. elegans microRNAs.},
  author={Yonatan H. Grad and John Aach and Gabriel D. Hayes and Brenda J. Reinhart and George M. Church and Gary Ruvkun and John W. Kim},
  journal={Molecular cell},
  volume={11 5},
MicroRNAs (miRNAs) constitute an extensive class of noncoding RNAs that are thought to regulate the expression of target genes via complementary base-pair interactions. To date, cloning has identified over 200 miRNAs from diverse eukaryotic organisms. Despite their success, such biochemical approaches are skewed toward identifying abundant miRNAs, unlike genome-wide, sequence-based computational predictions. We developed informatic methods to predict miRNAs in the C. elegans genome using… CONTINUE READING
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was used to test the effect of combinations of parameter settings used in generating predicted miRNA hairpin sets. The test set included several variants of let-7

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