Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers

@inproceedings{Prakash2017ComputationalAB,
  title={Computational and biochemical characterization of two partially overlapping interfaces and multiple weak-affinity K-Ras dimers},
  author={Priyanka Prakash and Abdallah Sayyed-Ahmad and Kwang-Jin Cho and Drew M Dolino and Wei Chen and Hongyang Li and Barry J. Grant and John F Hancock and Alemayehu A. Gorfe},
  booktitle={Scientific reports},
  year={2017}
}
Recent studies found that membrane-bound K-Ras dimers are important for biological function. However, the structure and thermodynamic stability of these complexes remained unknown because they are hard to probe by conventional approaches. Combining data from a wide range of computational and experimental approaches, here we describe the structure, dynamics, energetics and mechanism of assembly of multiple K-Ras dimers. Utilizing a range of techniques for the detection of reactive surfaces… CONTINUE READING