Computational and Experimental Study of the Mechanics of Embryonic Wound Healing

  title={Computational and Experimental Study of the Mechanics of Embryonic Wound Healing},
  author={Matthew A. Wyczalkowski and Victor D. Varner and Larry A. Taber},
Wounds in the embryo show a remarkable ability to heal quickly without leaving a scar. Previous studies have found that an actomyosin ring (“purse string”) forms around the wound perimeter and contracts to close the wound over the course of several dozens of minutes. Here, we report experiments that reveal an even faster mechanism which remarkably closes wounds by more than 50% within the first 30 seconds. Circular and elliptical wounds (∼100 μm in size) were made in the blastoderm of early… CONTINUE READING
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