Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress

@inproceedings{Mitchell2013ComputationalAE,
  title={Computational and Experimental Models of Cancer Cell Response to Fluid Shear Stress},
  author={Michael J. Mitchell and Michael R. King},
  booktitle={Front. Oncol.},
  year={2013}
}
It has become evident that mechanical forces play a key role in cancer metastasis, a complex series of steps that is responsible for the majority of cancer-related deaths. One such force is fluid shear stress, exerted on circulating tumor cells by blood flow in the vascular microenvironment, and also on tumor cells exposed to slow interstitial flows in the tumor microenvironment. Computational and experimental models have the potential to elucidate metastatic behavior of cells exposed to such… CONTINUE READING
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References

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Showing 1-10 of 134 references

Effect of the glycocalyx layer on transmission of interstitial flow shear stress to embedded cells.

Biomechanics and modeling in mechanobiology • 2013
View 6 Excerpts
Highly Influenced

Fluid Flow Mechanotransduction in Vascular Smooth Muscle Cells and Fibroblasts

Annals of Biomedical Engineering • 2011
View 6 Excerpts
Highly Influenced

Glycocalyx modulates the motility and proliferative response of vascular endothelium to fluid shear stress.

American journal of physiology. Heart and circulatory physiology • 2007
View 6 Excerpts
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