Computational analysis of the evolution of the structure and function of 1-deoxy-D-xylulose-5-phosphate synthase, a key regulator of the mevalonate-independent pathway in plants.


We investigated molecular evolution of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), an important regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Sequence alignment showed that some regions, likely to be functionally important, were highly conserved among all of the plant DXS sequences analysed. Phylogenetic… (More)