Computational analysis of open loop handwriting movements in Parkinson's disease: a rapid method to detect dopamimetic effects.

@article{Eichhorn1996ComputationalAO,
  title={Computational analysis of open loop handwriting movements in Parkinson's disease: a rapid method to detect dopamimetic effects.},
  author={Th. Eichhorn and Thomas Gasser and Norbert Mai and Christian Marquardt and Guy Arnold and Johannes Schwarz and Wolfgang Hermann Oertel},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1996},
  volume={11 3},
  pages={289-97}
}
We used a computational analysis of open loop handwriting movements and a clinical rating scale for monitoring the effect of apomorphine in 16 patients with early untreated parkinsonism [subsequently L-DOPA responsive, probable Parkinson's disease (PD)], six patients with long-standing PD with L-DOPA associated motor fluctuations, and seven patients with known L-DOPA unresponsive parkinsonism. Subjects were instructed to write fluently concentric circles of approximately 12 mm in diameter… CONTINUE READING