Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance

@article{Xin2009ComputationalAO,
  title={Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance},
  author={Fuxiao Xin and Meng Li and Curtis Balch and Michael Thomson and Meiyun Fan and Yunlong Liu and Scott M. Hammond and Sun Kim and Kenneth P. Nephew},
  journal={Bioinformatics},
  year={2009},
  volume={25 4},
  pages={430-4}
}
MOTIVATION Recent evidence shows significant involvement of microRNAs (miRNAs) in the initiation and progression of numerous cancers; however, the role of these in tumor drug resistance remains unknown. RESULTS By comparing global miRNA and mRNA expression patterns, we examined the role of miRNAs in resistance to the 'pure antiestrogen' fulvestrant, using fulvestrant-resistant MCF7-FR cells and their drug-sensitive parental estrogen receptor (ER)-positive MCF7 cells. We identified 14 miRNAs… CONTINUE READING
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