Computational analysis of interactomes: current and future perspectives for bioinformatics approaches to model the host-pathogen interaction space.

@article{Arnold2012ComputationalAO,
  title={Computational analysis of interactomes: current and future perspectives for bioinformatics approaches to model the host-pathogen interaction space.},
  author={Roland Arnold and Kurt Boonen and Mark G. F. Sun and Philip M. Kim},
  journal={Methods},
  year={2012},
  volume={57 4},
  pages={508-18}
}
Bacterial and viral pathogens affect their eukaryotic host partly by interacting with proteins of the host cell. Hence, to investigate infection from a systems' perspective we need to construct complete and accurate host-pathogen protein-protein interaction networks. Because of the paucity of available data and the cost associated with experimental approaches, any construction and analysis of such a network in the near future has to rely on computational predictions. Specifically, this… CONTINUE READING

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