Computational analysis of core promoters in the Drosophila genome

  title={Computational analysis of core promoters in the Drosophila genome},
  author={Uwe Ohler and Guo-chun Liao and Heinrich Niemann and Gerald M. Rubin},
  journal={Genome Biology},
  pages={research0087.1 - 87.12}
The core promoter, a region of about 100 base-pairs flanking the transcription start site (TSS), serves as the recognition site for the basal transcription apparatus. Drosophila TSSs have generally been mapped by individual experiments; the low number of accurately mapped TSSs has limited analysis of promoter sequence motifs and the training of computational prediction tools. We identified TSS candidates for about 2,000 Drosophila genes by aligning 5' expressed sequence tags (ESTs) from cap… CONTINUE READING
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