Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing.

@article{Brudno2001ComputationalAO,
  title={Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing.},
  author={Michael Brudno and Mikhail S. Gelfand and Sabrina Spengler and Manfred Zorn and Inna Dubchak and J. G. Conboy},
  journal={Nucleic acids research},
  year={2001},
  volume={29 11},
  pages={2338-48}
}
Alternative pre-mRNA splicing is a major cellular process by which functionally diverse proteins can be generated from the primary transcript of a single gene, often in tissue-specific patterns. The current study investigates the hypothesis that splicing of tissue-specific alternative exons is regulated in part by control sequences in adjacent introns and that such elements may be recognized via computational analysis of exons sharing a highly specific expression pattern. We have identified 25… CONTINUE READING
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