Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia

@inproceedings{Brown2012ComputationalAO,
  title={Computational analysis of calcium signaling and membrane electrophysiology in cerebellar Purkinje neurons associated with ataxia},
  author={Sherry-Ann Brown and Leslie M. Loew},
  booktitle={BMC Systems Biology},
  year={2012}
}
BackgroundMutations in the smooth endoplasmic reticulum (sER) calcium channel Inositol Trisphosphate Receptor type 1 (IP3R1) in humans with the motor function coordination disorders Spinocerebellar Ataxia Types 15 and 16 (SCA15/16) and in a corresponding mouse model, the IP3R1delta18/delta18 mice, lead to reduced IP3R1 levels. We posit that increasing IP3R1 sensitivity to IP3 in ataxias with reduced IP3R1 could restore normal calcium response. On the other hand, in mouse models of the human… CONTINUE READING
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