Computational analysis of binding between malarial dihydrofolate reductases and anti-folates

@inproceedings{Choowongkomon2009ComputationalAO,
  title={Computational analysis of binding between malarial dihydrofolate reductases and anti-folates},
  author={Kiattawee Choowongkomon and Sasikrit Theppabutr and Napat Songtawee and Nicholas P J Day and Nicholas J White and Charles J Woodrow and Mallika Imwong},
  booktitle={Malaria Journal},
  year={2009}
}
Plasmodium falciparum readily develops resistance to the anti-folates pyrimethamine and proguanil via a characteristic set of mutations in the dihydrofolate reductase (PfDHFR) gene that leads to reduced competitive drug binding at the enzyme's active site. Analogous mutations can be found in the DHFR gene in isolates of Plasmodium vivax (PvDHFR) although anti-folates have not been widely used for the treatment of this infection. Here the interactions between DHFR inhibitors and modelled… CONTINUE READING
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