Computational analysis and identification of amino acid sites in dengue E proteins relevant to development of diagnostics and vaccines

@article{Mazumder2007ComputationalAA,
  title={Computational analysis and identification of amino acid sites in dengue E proteins relevant to development of diagnostics and vaccines},
  author={Raja Mazumder and Zhang-Zhi Hu and C. R. Vinayaka and Jos{\'e}-Luis Sagripanti and Simon D. W. Frost and Sergei L. Kosakovsky Pond and Cathy H. Wu},
  journal={Virus Genes},
  year={2007},
  volume={35},
  pages={175-186}
}
We have identified 72 completely conserved amino acid residues in the E protein of major groups of the Flavivirus genus by computational analyses. In the dengue species we have identified 12 highly conserved sequence regions, 186 negatively selected sites, and many dengue serotype-specific negatively selected sites. The flavivirus-conserved sites included residues involved in forming six disulfide bonds crucial for the structural integrity of the protein, the fusion motif involved in viral… CONTINUE READING

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