Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology.

@article{Kleinstreuer2007ComputationalAO,
  title={Computational analyses of a pressurized metered dose inhaler and a new drug-aerosol targeting methodology.},
  author={Clement Kleinstreuer and Huawei Shi and Zhe Zhang},
  journal={Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine},
  year={2007},
  volume={20 3},
  pages={294-309}
}
The popular pressurized metered dose inhaler (pMDI), especially for asthma treatment, has undergone various changes in terms of propellant use and valve design. Most significant are the choice of hydrofluoroalkane-134a (HFA-134a) as a new propellant (rather than chlorofluorocarbon, CFC), a smaller exit nozzle diameter and attachment of a spacer in order to reduce ultimately droplet size and spray inhalation speed, both contributing to higher deposition efficiencies and hence better asthma… CONTINUE READING