Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis

  title={Computational Psychiatry of ADHD: Neural Gain Impairments across Marrian Levels of Analysis},
  author={Tobias U. Hauser and Vincenzo G. Fiore and Michael Moutoussis and Raymond J. Dolan},
  journal={Trends in Neurosciences},
Attention-deficit hyperactivity disorder (ADHD), one of the most common psychiatric disorders, is characterised by unstable response patterns across multiple cognitive domains. However, the neural mechanisms that explain these characteristic features remain unclear. Using a computational multilevel approach, we propose that ADHD is caused by impaired gain modulation in systems that generate this phenotypic increased behavioural variability. Using Marr's three levels of analysis as a heuristic… CONTINUE READING
Highly Cited
This paper has 72 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 73 times. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 17 extracted citations

72 Citations

Citations per Year
Semantic Scholar estimates that this publication has 72 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 77 references

Role of the medial prefrontal cortex in impaired decision making in juvenile attention-deficit/hyperactivity disorder

Hauser, T.U
JAMA Psychiatry • 2014
View 5 Excerpts
Highly Influenced

Attention-deficit/hyperactivity disorder

Faraone, S.V
Nat. Rev. Dis. Primer. Published online August • 2015
View 4 Excerpts
Highly Influenced

The effects of neural gain on attention and learning

E Eldar
Nat. Neurosci • 2013
View 4 Excerpts
Highly Influenced

The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/ hyperactivity disorder

N Del Campo
Biol. Psychiatry • 2011
View 4 Excerpts
Highly Influenced

Active inference and epistemic value.

Cognitive neuroscience • 2015
View 1 Excerpt

Similar Papers

Loading similar papers…