Computational Prediction of Synthetic Lethals in Genome-Scale Metabolic Models Using Fast-SL.

Abstract

In this chapter, we describe Fast-SL, an in silico approach to predict synthetic lethals in genome-scale metabolic models. Synthetic lethals are sets of genes or reactions where only the simultaneous removal of all genes or reactions in the set abolishes growth of an organism. In silico approaches to predict synthetic lethals are based on Flux Balance… (More)
DOI: 10.1007/978-1-4939-7528-0_14

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@article{Raman2018ComputationalPO, title={Computational Prediction of Synthetic Lethals in Genome-Scale Metabolic Models Using Fast-SL.}, author={Karthik Raman and Aditya Pratapa and Omkar Mohite and Shankar Balachandran}, journal={Methods in molecular biology}, year={2018}, volume={1716}, pages={315-336} }