Computational Prediction of Conformational B-Cell Epitopes from Antigen Primary Structures by Ensemble Learning

@inproceedings{Zhang2012ComputationalPO,
  title={Computational Prediction of Conformational B-Cell Epitopes from Antigen Primary Structures by Ensemble Learning},
  author={Wen Zhang and Yanqing Niu and Yi Xiong and Meng Zhao and Rongwei Yu and Juan Liu},
  booktitle={PloS one},
  year={2012}
}
MOTIVATION The conformational B-cell epitopes are the specific sites on the antigens that have immune functions. The identification of conformational B-cell epitopes is of great importance to immunologists for facilitating the design of peptide-based vaccines. As an attempt to narrow the search for experimental validation, various computational models have been developed for the epitope prediction by using antigen structures. However, the application of these models is undermined by the limited… CONTINUE READING
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Prediction of residues in discontinuous B cell epitopes using protein 3D structures

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