Computational Modelling of Cancer Development and Growth: Modelling at Multiple Scales and Multiscale Modelling

  title={Computational Modelling of Cancer Development and Growth: Modelling at Multiple Scales and Multiscale Modelling},
  author={Zuzanna Szymanska and Maciej Cytowski and Elaine Irwin Mitchell and Cicely K. Macnamara and Mark A. J. Chaplain},
  journal={Bulletin of Mathematical Biology},
In this paper, we present two mathematical models related to different aspects and scales of cancer growth. The first model is a stochastic spatiotemporal model of both a synthetic gene regulatory network (the example of a three-gene repressilator is given) and an actual gene regulatory network, the NF-$$\upkappa $$κB pathway. The second model is a force-based individual-based model of the development of a solid avascular tumour with specific application to tumour cords, i.e. a mass of cancer… 
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