Computational Modeling of T Cell Receptor Complexes.

  title={Computational Modeling of T Cell Receptor Complexes.},
  author={Timothy P. Riley and Nishant K. Singh and Brian G. Pierce and Zhiping Weng and Brian M. Baker},
  journal={Methods in molecular biology},
T-cell receptor (TCR) binding to peptide/MHC determines specificity and initiates signaling in antigen-specific cellular immune responses. Structures of TCR-pMHC complexes have provided enormous insight to cellular immune functions, permitted a rational understanding of processes such as pathogen escape, and led to the development of novel approaches for the design of vaccines and other therapeutics. As production, crystallization, and structure determination of TCR-pMHC complexes can be… CONTINUE READING