Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases

Abstract

The emerging structural information about allosteric kinase complexes and the growing number of allosteric inhibitors call for a systematic strategy to delineate and classify mechanisms of allosteric regulation and long-range communication that control kinase activity. In this work, we have investigated mechanistic aspects of long-range communications in… (More)
DOI: 10.1371/journal.pcbi.1002179

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Cite this paper

@inproceedings{Dixit2011ComputationalMO, title={Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases}, author={Anshuman Dixit and Gennady M Verkhivker}, booktitle={PLoS Computational Biology}, year={2011} }