Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast

@article{Cao2003ComputationalMA,
  title={Computational Modeling and Experimental Analysis of Nonsense-Mediated Decay in Yeast},
  author={Dan Cao and Roy Parker},
  journal={Cell},
  year={2003},
  volume={113},
  pages={533-545}
}
A conserved mRNA surveillance system, referred to as nonsense-mediated decay (NMD), exists in eukaryotic cells to degrade mRNAs containing nonsense codons. This process is important in checking that mRNAs have been properly synthesized and functions, at least in part, to increase the fidelity of gene expression by degrading aberrant mRNAs that, if translated, would produce truncated proteins. Using computational modeling and experimental analysis, we define the alterations in mRNA turnover… CONTINUE READING

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