Computational Model of Touch Sensory Cells (T Cells) of the Leech: Role of the Afterhyperpolarization (AHP) in Activity-Dependent Conduction Failure

@article{Cataldo2005ComputationalMO,
  title={Computational Model of Touch Sensory Cells (T Cells) of the Leech: Role of the Afterhyperpolarization (AHP) in Activity-Dependent Conduction Failure},
  author={Enrico Cataldo and Marcello Brunelli and John H. Byrne and Evyatar Av-Ron and Yidao Cai and Douglas A. Baxter},
  journal={Journal of Computational Neuroscience},
  year={2005},
  volume={18},
  pages={5-24}
}
Bursts of spikes in T cells produce an AHP, which results from activation of a Na+/K+ pump and a Ca2+-dependent K+ current. Activity-dependent increases in the AHP are believed to induce conduction block of spikes in several regions of the neuron, which in turn, may decrease presynaptic invasion of spikes and thereby decrease transmitter release. To explore this possibility, we used the neurosimulator SNNAP to develop a multi-compartmental model of the T cell. The model incorporated empirical… CONTINUE READING

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The contribution of membrane hyperpolarization to adaptation and conduction block in sensory neurones of the leech

  • DC Van Essen
  • J. Physiol. (Lond.)
  • 1973
Highly Influential
7 Excerpts

Neuroscience—A mathematical primer

  • A Scott
  • 2002
Highly Influential
4 Excerpts

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