Computational Methods for MicroRNA Target Prediction

  title={Computational Methods for MicroRNA Target Prediction},
  author={Semih Ekimler and Kaniye Sahin},
  booktitle={Methods in molecular biology},
MicroRNAs (miRNAs) are important players in gene regulation. The final and maybe the most important step in their regulatory pathway is the targeting. Targeting is the binding of the miRNA to the mature RNA via the RNA-induced silencing complex. Expression patterns of miRNAs are highly specific in respect to external stimuli, developmental stage, or tissue. This is used to diagnose diseases such as cancer in which the expression levels of miRNAs are known to change considerably. Newly… CONTINUE READING