Computational Methods for GPCR Drug Discovery

  title={Computational Methods for GPCR Drug Discovery},
  author={Alexander Heifetz},
  booktitle={Methods in Molecular Biology},
GPCRs play a pervasive physiological role and, in turn, are the leading target class for pharmaceuticals. Beginning with the determination of the structure of rhodopsin, and dramatically accelerating since the reporting of the first ligand-mediated GPCR X-ray structures, our understanding of the structural and functional characteristics of these proteins has grown dramatically. Deploying this now rapidly emerging information for drug discovery has already been extensively demonstrated through a… CONTINUE READING
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