Computational Identification and Experimental Validation of MicroRNAs Binding to the Fragile X Syndrome Gene Fmr1

Abstract

MicroRNAs (miRNAs) usually bind to their target mRNAs through imperfect base pairing in the 3′-untranslated regions (3′ UTRs) and regulate target gene expression via post-transcriptional suppression. In recent years, computational approaches to predict miRNA targets have facilitated the identification of potential target sites. In this study, we used three… (More)
DOI: 10.1007/s11064-014-1471-3

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