Computational Exploration of Natural Compounds to Target Cytosolic Phospholipase A 2 Protein: A Novel Therapeutic Target for Spinal Cord Injury.

@article{Fan2018ComputationalEO,
  title={Computational Exploration of Natural Compounds to Target Cytosolic Phospholipase A 2 Protein: A Novel Therapeutic Target for Spinal Cord Injury.},
  author={Hongwu Fan and Shengqun Wang and Qiheng Zhao and Zhigang Qin},
  journal={Current computer-aided drug design},
  year={2018},
  volume={14 2},
  pages={117-124}
}
BACKGROUND Cytosolic Phospholipase A2 (cPLA2), an important isoform of PLA2 that mediates the release of arachidonic acid, plays a role in the pathogenesis of Spinal Cord Injury (SCI). The expression and activation of Cpla2 are significantly higher in SCI, leading to neuronal death in spinal cord tissue. Novel strategies are needed to substantially reverse… CONTINUE READING