Computational Coevolution of Antiviral Drug Resistance

@article{Rosin1998ComputationalCO,
  title={Computational Coevolution of Antiviral Drug Resistance},
  author={Christopher D. Rosin and Richard K. Belew and Garrett M. Morris and Arthur J. Olson and David S. Goodsell},
  journal={Artificial Life},
  year={1998},
  volume={4},
  pages={41-59}
}
An understanding of antiviral drug resistance is important in the design of effective drugs. Comprehensive features of the interaction between drug designs and resistance mutations are difficult to study experimentally because of the very large numbers of drugs and mutants involved. We describe a computational framework for studying antiviral drug resistance. Data on HIV-1 protease are used to derive an approximate model that predicts interaction of a wide range of mutant forms of the protease… CONTINUE READING

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