Computation‐Guided Design of a Stimulus‐Responsive Multienzyme Supramolecular Assembly

@article{Yang2017ComputationGuidedDO,
  title={Computation‐Guided Design of a Stimulus‐Responsive Multienzyme Supramolecular Assembly},
  author={Lu Yang and Elliott M Dolan and Sophia K Tan and Tianyun Lin and Eduardo Sontag and Sagar D. Khare},
  journal={ChemBioChem},
  year={2017},
  volume={18}
}
The construction of stimulus-responsive supramolecular complexes of metabolic pathway enzymes, inspired by natural multienzyme assemblies (metabolons), provides an attractive avenue for efficient and spatiotemporally controllable one-pot biotransformations. We have constructed a phosphorylation- and optically responsive metabolon for the biodegradation of the environmental pollutant 1,2,3-trichloropropane. 
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