Compulsory hyperventilation and hypocapnia of patients with Leigh syndrome associated with SURF1 gene mutations as a cause of low serum bicarbonates

@article{Pronicka2001CompulsoryHA,
  title={Compulsory hyperventilation and hypocapnia of patients with Leigh syndrome associated with SURF1 gene mutations as a cause of low serum bicarbonates},
  author={Ewa Pronicka and Dorota Piekutowska-Abramczuk and Ewa Popowska and Maciej Pronicki and Elżbieta Karczmarewicz and Y. Sykut-Cegielsk{\^a} and Joanna Taybert},
  journal={Journal of Inherited Metabolic Disease},
  year={2001},
  volume={24},
  pages={707-714}
}
Experimental data show that elevation of intracellular pH leads to severe lesions of brain cells. Acidification of intracellular fluid by accumulation of lactate may compensate the effect of respiratory alkalosis. Increased serum pH, and low PCO2, associated with hyperlactataemia (sometimes incorrectly called ‘acidosis’) have been reported in children with Leigh syndrome (LS). The aim of the study was to determine whether respiratory alkalosis is characteristic of patients with LS due to SURF1… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…