Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.

@article{Oruqaj2015CompromisedPI,
  title={Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.},
  author={Gani Oruqaj and Srikanth Karnati and Vijith Vijayan and Lakshmi Kanth Kotarkonda and Eistine Boateng and Wenming Zhang and Clemens Ruppert and Andreas Guenther and Wei Shi and Eveline Baumgart-Vogt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 16},
  pages={
          E2048-57
        }
}
Idiopathic pulmonary fibrosis (IPF) is a devastating disease, and its pathogenic mechanisms remain incompletely understood. Peroxisomes are known to be important in ROS and proinflammatory lipid degradation, and their deficiency induces liver fibrosis. However, altered peroxisome functions in IPF pathogenesis have never been investigated. By comparing peroxisome-related protein and gene expression in lung tissue and isolated lung fibroblasts between human control and IPF patients, we found that… CONTINUE READING

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