Compromised local control due to treatment interruptions and late treatment breaks in early glottic cancer: Population-based outcomes study supporting need for intensified treatment schedules.

@article{Groome2006CompromisedLC,
  title={Compromised local control due to treatment interruptions and late treatment breaks in early glottic cancer: Population-based outcomes study supporting need for intensified treatment schedules.},
  author={Patti A. Groome and B O'Sullivan and William J. Mackillop and Lynda D Jackson and Karleen Schulze and Jonathan C. Irish and Padraig Richard Warde and Ken M. Schneider and Robert G. Mackenzie and D. I. Hodson and James R Hammond and Sunil P P Gulavita and Libni J. Eapen and Peter F. Dixon and Randy J Bissett},
  journal={International journal of radiation oncology, biology, physics},
  year={2006},
  volume={64 4},
  pages={
          1002-12
        }
}
PURPOSE This population-based study describes the treatment of early glottic cancer in Ontario, Canada and assesses whether treatment variations were associated with treatment effectiveness. METHODS AND MATERIALS We studied 491 T1N0 and 213 T2N0 patients. Data abstracted from charts included age, sex, stage, treatment details, disease control, and survival. RESULTS The total dose ranged from 50 to 70 Gy, and the daily dose ranged from 1.9 to 2.8 Gy. In 90%, treatment duration was between 25… CONTINUE READING

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