Compromised late-stage motion processing in schizophrenia

  title={Compromised late-stage motion processing in schizophrenia},
  author={Yue Chen and Deborah L. Levy and Summer L. Sheremata and Philip S. Holzman},
  journal={Biological Psychiatry},

Magnocellular contributions to impaired motion processing in schizophrenia

Dysfunction of Magnocellular/dorsal Processing Stream in Schizophrenia

  • S. Chieffi
  • Psychology, Biology
    Current Psychiatry Research and Reviews
  • 2019
Early magnocellular dysfunction may provide a substrate for late dorsal processing impairment as well as higher-level cognition deficits, and neurophysiological and behavioral studies support the existence of deficits in the processing of visual information along the mag nocellular/dorsal pathway.

Abnormal visual motion processing in schizophrenia: a review of research progress.

  • Y. Chen
  • Psychology
    Schizophrenia bulletin
  • 2011
This article surveys the behavioral and neuroimaging studies that probe into the spatial integration of motion information in schizophrenia and points to an imbalanced regulation of spatial interaction processes as a potential mechanism mediating different levels of abnormal motion processing in schizophrenia.

Early-stage visual processing deficits in schizophrenia

Understanding the nature of sensory processing deficits may provide insight into mechanisms of pathology in schizophrenia, such as N-methyl-D-aspartate dysfunction or impaired signal amplification, and could lead to treatment strategies including sensory processing rehabilitation that may improve outcome.

Magnocellular Pathway Impairment in Schizophrenia: Evidence from Functional Magnetic Resonance Imaging

The hypothesis that schizophrenia is associated with impaired functioning of the magnocellular visual pathway is supported and these sensory processing deficits may contribute to higher-order cognitive deficits in working memory, executive functioning, and attention.

Weakened Center-Surround Interactions in Visual Motion Processing in Schizophrenia

It is shown that schizophrenic patients exhibit abnormally weak center-surround suppression in motion, an abnormality that is most pronounced in patients with severe negative symptoms, and patients with the weakest surround suppression outperformed control subjects in motion discriminations of large high-contrast stimuli.



Motion perception in schizophrenia.

The discrimination of small velocity differences is impaired in a subgroup of patients with schizophrenia, and both motion signals and the brain regions responsible for processing motion signals are implicated in the generation of smooth pursuit.

Psychophysical isolation of a motion-processing deficit in schizophrenics and their relatives and its association with impaired smooth pursuit.

It is reported that the motion discrimination deficit, which occurs in both schizophrenic patients and in their first-degree relatives, involves a failure of velocity detection, which appears when judging intermediate target velocities and is associated with sluggish initiation of smooth pursuit.

Dependence of impaired eye tracking on deficient velocity discrimination in schizophrenia.

Deficient processing of velocity information seems to be one component that contributes to a dysfunction in the initiation and maintenance of smooth pursuit in schizophrenia.

The characteristics of residual motion perception in the hemifield contralateral to lateral occipital lesions in humans.

It is concluded that the degraded motion perception is mediated by mechanisms which have similar contrast and temporal properties to those subserving normal motion perception, which resembles that described in some recent animal studies of impaired motion perception after extra-striate cortical damage.

Deficits in speed discrimination following lesions of the lateral suprasylvian cortex in the cat

It appears that information needed for discriminating opposite directions of motion may be signalled by visual areas outside LS, as three cats showed permanent deficits in discriminating differences in speed and in flicker rate.

Smooth pursuit eye movements to extraretinal motion signals: deficits in relatives of patients with schizophrenia.

These results suggest that relatives of patients with schizophrenia, particularly those with SSP, have specific deficits in predictive pursuit based on only extraretinal motion signals, which is likely due to compensation based on retinal motion information.

The relationship between smooth pursuit performance, motion perception and sustained visual attention in patients with schizophrenia and normal controls

Brain area V5, located in the parieto-occipital region, is known to be critically important both for motion perception and gain and the results point to an abnormality in this area in schizophrenia.