Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice.

@article{Belz2002CompromisedIV,
  title={Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice.},
  author={Gabrielle T. Belz and Dominik Wodarz and Gabriela Diaz and Martin A. Nowak and Peter C. Doherty},
  journal={Journal of virology},
  year={2002},
  volume={76 23},
  pages={
          12388-93
        }
}
The primary influenza A virus-specific CD8(+)-T-cell responses measured by tetramer staining of spleen, lymph node, and bronchoalveolar lavage (BAL) lymphocyte populations were similar in magnitude for conventional I-A(b+/+) and CD4(+)-T-cell-deficient I-A(b-/-) mice. Comparable levels of virus-specific cytotoxic-T-lymphocyte activity were detected in the inflammatory exudate recovered by BAL following challenge. However, both the size of the memory T-cell pool and the magnitude of the recall… CONTINUE READING

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