Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice.

  title={Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice.},
  author={Nico Ghilardi and Noelyn M Kljavin and Qi Chen and Sophie Lucas and Austin L. Gurney and Frederic J de Sauvage},
  journal={Journal of immunology},
  volume={172 5},
The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12. Previously reported IL-12p40-deficient mice have profound immune defects resulting from combined deficiency in both IL-12 and IL-23. To address the effects of specific IL-23 deficiency, we generated mice lacking p19 by gene targeting. These mice display no overt abnormalities but mount severely compromised T-dependent humoral immune responses… CONTINUE READING
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