Compromised gut microbiota networks in children with anti-islet cell autoimmunity.

  title={Compromised gut microbiota networks in children with anti-islet cell autoimmunity.},
  author={David Endesfelder and Wolfgang zu Castell and Alexandria N. Ardissone and Austin G. Davis-Richardson and Peter Achenbach and Michael Hagen and Maren Pflueger and Kelsey A. Gano and Jennie R. Fagen and Jennifer C. Drew and C. Titus Brown and Bryan Kolaczkowski and Mark A Atkinson and Desmond A Schatz and Ezio Bonifacio and E. W. Triplett and Anette-G. Ziegler},
  volume={63 6},
The gut microbiome is suggested to play a role in the pathogenesis of autoimmune disorders such as type 1 diabetes. Evidence of anti-islet cell autoimmunity in type 1 diabetes appears in the first years of life; however, little is known regarding the establishment of the gut microbiome in early infancy. Here, we sought to determine whether differences were present in early composition of the gut microbiome in children in whom anti-islet cell autoimmunity developed. We investigated the… CONTINUE READING