Compromised fronto-striatal functioning in HIV: An fMRI investigation of semantic event sequencing

@article{Melrose2008CompromisedFF,
  title={Compromised fronto-striatal functioning in HIV: An fMRI investigation of semantic event sequencing},
  author={Rebecca J. Melrose and Sule Tinaz and J. Mimi Boer Castelo and Maureen G. Courtney and Chantal E. Stern},
  journal={Behavioural Brain Research},
  year={2008},
  volume={188},
  pages={337-347}
}
The human immunodeficiency virus (HIV) damages fronto-striatal regions, and is associated with deficits in executive functioning. We recently developed a semantic event sequencing task based on the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-III for use with functional magnetic resonance imaging (fMRI) and found recruitment of dorsolateral prefrontal cortex and basal ganglia in healthy participants. To assess the impact of HIV on the functioning of the basal ganglia and… Expand
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