Compromised autophagy and neurodegenerative diseases

@article{Menzies2015CompromisedAA,
  title={Compromised autophagy and neurodegenerative diseases},
  author={Fiona Mhairi Menzies and Angeleen Fleming and David C Rubinsztein},
  journal={Nature Reviews Neuroscience},
  year={2015},
  volume={16},
  pages={345-357}
}
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial dysfunction. Autophagy is a powerful process for removing such proteins and for maintaining mitochondrial homeostasis. Over recent years, evidence has accumulated to demonstrate that upregulation of autophagy may protect against neurodegeneration. However, autophagy dysfunction has also been implicated in the pathogenesis of… CONTINUE READING
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