Compromised autophagy and neurodegenerative diseases

  title={Compromised autophagy and neurodegenerative diseases},
  author={Fiona Mhairi Menzies and Angeleen Fleming and David C Rubinsztein},
  journal={Nature Reviews Neuroscience},
Most neurodegenerative diseases that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins in neurons and with mitochondrial dysfunction. Autophagy is a powerful process for removing such proteins and for maintaining mitochondrial homeostasis. Over recent years, evidence has accumulated to demonstrate that upregulation of autophagy may protect against neurodegeneration. However, autophagy dysfunction has also been implicated in the pathogenesis of… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 17 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
127 Citations
191 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 127 extracted citations


Publications referenced by this paper.
Showing 1-10 of 191 references

Similar Papers

Loading similar papers…