Compressive mechanical force augments osteoclastogenesis by bone marrow macrophages through activation of c-Fms-mediated signaling.

@article{Cho2010CompressiveMF,
  title={Compressive mechanical force augments osteoclastogenesis by bone marrow macrophages through activation of c-Fms-mediated signaling.},
  author={Eul Saeng Cho and Kyongsoo Lee and Young-Ok Son and Yong-Suk Jang and Seung-Youp Lee and So-Yeong Kwak and Yungkai Yang and Seung Moon Park and Jiahong Lee},
  journal={Journal of cellular biochemistry},
  year={2010},
  volume={111 5},
  pages={
          1260-9
        }
}
Little is known about the effects of mechanical forces on osteoclastogenesis by bone marrow macrophages (BMMs) in the absence of mechanosensitive cells, including osteoblasts and fibroblasts. In this study, we examined the effects of mechanical force on osteoclastogenesis by applying centrifugal force to BMMs using a horizontal microplate rotor. Our findings, as measured by an in vitro model system, show that tumor necrosis factor (TNF)-α is capable of inducing osteoclast differentiation from… CONTINUE READING
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