Compressive compared with tensile loading of medial collateral ligament scar in vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase.

@article{Majima2000CompressiveCW,
  title={Compressive compared with tensile loading of medial collateral ligament scar in vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase.},
  author={Tokifumi Majima and Linda L Marchuk and Paul Sciore and Nigel G. Shrive and Cyril B. Frank and David A. Hart},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2000},
  volume={18 4},
  pages={524-31}
}
To test the hypothesis that loading conditions can be used to engineer early ligament scar behaviors, we used an in vitro system to examine the effect that cyclic hydrostatic compression and cyclic tension applied to 6-week rabbit medial collateral ligament scars had on mRNA levels for matrix molecules, collagenase, and the proto-oncogenes c-fos and c-jun… CONTINUE READING