Compressive Force Spectroscopy: From Living Cells to Single Proteins

@inproceedings{Wang2018CompressiveFS,
  title={Compressive Force Spectroscopy: From Living Cells to Single Proteins},
  author={Jiabin Wang and Meijun Liu and Yi Shen and Jielin Sun and Zhifeng Shao and Daniel Mark Czajkowsky},
  booktitle={International journal of molecular sciences},
  year={2018}
}
One of the most successful applications of atomic force microscopy (AFM) in biology involves monitoring the effect of force on single biological molecules, often referred to as force spectroscopy. Such studies generally entail the application of pulling forces of different magnitudes and velocities upon individual molecules to resolve individualistic unfolding/separation pathways and the quantification of the force-dependent rate constants. However, a less recognized variation of this method… CONTINUE READING

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