Compressibility as a means to detect and characterize globular protein states.

  title={Compressibility as a means to detect and characterize globular protein states.},
  author={Tigran V Chalikian and Kenneth J. Breslauer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 3},
We report compressibility data on single-domain, globular proteins which suggest a general relationship between protein conformational transitions and delta kzeroS, the change in the partial specific adiabatic compressibility which accompanies the transition. Specifically, we find transitions between native and compact intermediate states to be accompanied by small increases in kzeroS of +(1-4) x 10(-6) (1 bar = 100 kPa). By contrast, transitions between native and partially… CONTINUE READING

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