Comprehensive review: antitumor necrosis factor agents in inflammatory bowel disease and factors implicated in treatment response.

@article{Lichtenstein2013ComprehensiveRA,
  title={Comprehensive review: antitumor necrosis factor agents in inflammatory bowel disease and factors implicated in treatment response.},
  author={Gary R. Lichtenstein},
  journal={Therapeutic advances in gastroenterology},
  year={2013},
  volume={6 4},
  pages={269-93}
}
Antitumor necrosis factor α (anti-TNF) agents have dramatically influenced management of refractory inflammatory bowel disease (IBD). However, not all patients respond to treatment and some lose response or become intolerant over time. Immunogenicity, a well established phenomenon with anti-TNF agents, may have important clinical implications in patients with IBD. A comprehensive review of available evidence demonstrating how drug concentrations, immunogenicity, and other factors influence… CONTINUE READING